How Long and How Strong Do Our Immune System Protections Last after a COVID Vaccination or COVID Infection

June 21, 2021

  • While surveying over 130 COVID, SARS & vaccine scientific reports, we found some interesting results that describe our COVID post-vaccine & post-infection protection levels, including how long & how strong our immune system protections remain from 1 month to 8 months later.

https://science.sciencemag.org/content/371/6529/eabf4063?fbclid=IwAR0sYfYKnv-WHnxWU9v48TR-pmqVQ1gzsyUd1yzo8ASLIr1-nFxkt5ZyWdg

The study was not large … but they analyzed a decent number of patient samples for the 4 general key long-term protective immune system components-reactions … to determine what COVID protections we maintain for 1 month, 4 months, 6 months and 8 months after vaccination and natural infections. … Because some of the results are reported for patients who only had natural COVID infections, we are left to extrapolate the expected protections we get from vaccinations.**   

Researchers monitored 4 groups of our key immune system responses to COVID infections & COVID vaccinations – for up to 8 months after vaccination/infection.  Their goals were:

~ to see what specific protective responses our bodies had

~ to see how strong (effective) those protective responses were … and

~ to see how long each of those 4 different kinds of protective responses lasted.


Overall Conclusions … The researchers  found that after COVID vaccinations & infections:
Roughly 95% of subjects retained good levels of immune memory at ~6 months after infection or vaccination.

Blood samples showed good levels of circulating COVID antibody titers in lab tests, (where COVID antibody titers are the typical lab test used by Medical Doctors to monitor our COVID protection  … Yet, those laboratory test results used by Medical doctors    did NOT reflect,   did NOT represent  our T cell memory cell levels.   … Fortunately, our key protective memory T-cell levels were generally higher than the Antibody test results …  Still, one memory cell component levels were lower than predicted~reflected by Antibody test results after 8 months.

This means that the current simple serological tests for SARS-CoV-2 antibodies DO NOT REFLECT the richness and durability of our protective, immune memory reactions to SARS-CoV-2.




Scientific Conclusions:
1.  Antibodies against SARS-CoV-2 spike proteins and receptor binding domain (RBD) declined moderately over 8 months.

This points to some patients (esp older people) possibly needing a booster shot 8 months after the 2’nd vaccination shot.

All of these results compared very well with the findings of several other reports. … Example, Pfizer found good levels of antibody protection after 6 months …. yet 22% of elderlies over age 80 had NO memory B-cells and NO memory T-cells left after the Pfizer vaccine after just 6 month… but those elderlies still had modest levels of neutralizing antibodies after 6 months … giving the elderlies some remaining protection.

2.   Memory B cells against SARS-CoV-2 spike actually increased between 1 month and 8 months after infection.
YAY !

3.   Memory CD8+ T cells and memory CD4+ T cells declined with an initial half-life of 3 to 5 months.

Half Life means half is gone after the reported time period…  50% lower after 4 months … 25% remaining after 8 months … 12% remaining after 12 months.

This is GOOD news, because the vaccines typically cause our bodies to make 10X to 1000X more of the protective components than a natural COVID infection …

which means when vaccinated … most of us still likely have decent protection after a year.

4.  Immunoglobulin G (IgG), RBD IgG, and neutralizing antibody titers  to COVID-spike-proteins
 … exhibited similar changes over time.

5. Specifically…. Spike IgA was still present in the large majority of subjects at 6 to 8 months after infection.
YAY

6.  IgG was the dominant isotype of our memory B cell responses … as IgM memory B cells appeared to be short-lived.

7.  They found a minor population of IgA memory B cells.

7.a. CD8+ T cell and CD4+ T cell memory were measured for all SARS-CoV-2 proteins.

7.b.  70% of individuals possessed detectable CD8+ T cell memory at 1 month after infection, that declined to ~50% by 6 to 8 months after infection.
YAY

7.c.  CD4+ T cell memory had 93% of subjects wutg detectable SARS-CoV-2 memory at 1 month after infection.

7.d.  92% of patients had high levels of CD4+ T cells (92%) remained high at 6 to 8 months after infection.

YAY

We would expect vaccinated patients to perform similarly – or better than natural COVID infected patients based on other COVID study results.

7.e.   SARS-CoV-2 spike-specific memory CD4+ T cells with the specialized capacity to help B cells [T follicular helper (TFH) cells] were also maintained.

The BIG Over-Arching Conclusions:
  Roughly 95% of subjects retained good levels of immune memory at ~6 months after infection or vaccination.

Blood samples showed good levels of circulating COVID antibody titers in lab tests, (where COVID antibody titers are the typical lab test used by Medical Doctors to monitor our COVID protection  … and those laboratory test results used by Medical doctors    did NOT reflect,   did NOT represent  our T cell memory cell levels.   … Our key protective memory T-cell levels were generally higher than the Antibody test results …  yet one memory cell component was lower than predicted~reflected by Antibody test results after 8 months.

This means that the current simple serological tests for SARS-CoV-2 antibodies DO NOT REFLECT the richness and durability of our protective, immune memory reactions to SARS-CoV-2.

Unfortunately… The scientific report also shows that Medical Doctors are (sadly broadly generally) behind the scientific facts curve … again. … because Medical Doctors are AGAIN relying on  too narrow of lab test results   that do not represent    our actual immune system protections.

which means we need to continue to rely on talented Scientists,  not Medical Doctors, for the best information on how to stay safe from COVID.

Dr. Steve 

= = = = = = = = = = =
  **Numerous studies have consistently shown vaccines cause our bodies to make between 10X to 100X and up to 10,000X higher levels of neutralizing antibodies & T-cells against SARS-CoV-2, to protect us against COVID … so it is reasonable to expect that our long term immune system protections from vaccinations are    better   than the results presented below for patients who had natural infections.






~ Stay well, stay informed, stay safe. ~


The Good Doctor Fry
Steven Michael Fry

Ph.D. Analytical Chemistry, Aerosol Science, Measurement Science, Public Health & Environment

Read On … MacDuff !

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1 Response to How Long and How Strong Do Our Immune System Protections Last after a COVID Vaccination or COVID Infection

  1. Pingback: FYI | Chicxulub Food Bank Yucatan Mexico |

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